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BH3 Mimetic ABT-737 is an orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein family, including Bcl-2, Bcl-xl and Bcl-w. ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2. Selleck's ABT-737 has been cited by 299 publications ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

Abt 737

15, Alingsås, 51, 18, 27 Jernberg-Wiklund H, Loskog, S I A. ABT-737 blockade of. Bcl-2 family apoptosis inhibitors sensitizes B-cell tumors to CAR-T-cell killing. Cancer Gene Ther. 2013 ABT. S200.

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Bcl-2 proteins play an important role in cell survival and have been shown to be overexpressed in many tumors. ABT 737 also inhibits Bcl-w and Bcl-xl.

ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and small-cell lung cancer in preclinical studies. We here report that ABT-737 effectively kills acute myeloid leukemia bla …. BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that BH3 mimetic ABT-737 induces apoptosis. Sample Page Supplementary MaterialsSupplementary Information 41467_2018_7213_MOESM1_ESM. March 10, 2021 by abt737 ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Howard AN(1), Bridges KA, Meyn RE, Chandra J. Author information: (1)Department of Pediatrics Research, The University of Texas M D Anderson Cancer Center, Box 853, 1515 Holcombe Blvd, Houston, TX 77030, USA. ABT-737 Cat. No.: A8193 CAS No.: 852808-04-9 Formula: C42H45ClN6O5S2 M.Wt: 813.43 Synonyms: ABT 737, ABT737 Target: Apoptosis Pathway: Bcl-2 Family Storage: Store at -20°C In Vitro ≥40.67mg/mL in DMSO,insoluble in EtOH,insoluble in H2O Preparing Stock Solutions Mass Solvent 1mg 5mg 10mg Concentration 1 mM 1.2294 mL 6.1468 mL 12.2936 mL ABT-737 is a novel and potent pan Bcl-2 inhibitor.
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ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Kline et al. Leukemia, 2007;21:1549 Product Datasheets ABT-737 disturbs the binding of B cell lymphoma (Bcl)-2 homologous antagonist killer and Bcl-extra large.
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The previous studies reported that DM-NCTD could enhance ABT-737-triggered cell viability inhibition and apoptosis in hepatocellular carcinoma (HCC) cell lines. To translate this synergistic therapy into in vivo anticancer treatment, a folate receptor-targeted lipid bilayer ABT-737 induced oxidative stress through decreased GSH and increased intracellular hydrogen peroxide and superoxide levels. Apoptotic DNA fragmentation and caspase activation were the consequences of this oxidative stress. Combining ABT-737 with ROS-inducing agents such as adaphostin or etoposide enhanced cell death. ABT-737 through the regulation of Mcl-1 level.